A blister is friction plus moisture plus time. Remove any one of the three and it does not form.

Blisters end more trips than any injury other than a rolled ankle, and they are close to fully preventable. The mechanism is shear between skin layers, made much worse by moisture. Once you know where your feet rub, you tape those spots before you walk, not after they hurt.
Do a loaded walk at home. Everyone has a personal map: heel cup, outside of the little toe, the ball under the big toe. That map barely changes over years.
Leukotape on clean dry skin over the known spots before you start walking. It stays on for days including through water. Apply smooth with no wrinkles, because a wrinkle is a new friction point.
Heel lift means your lacing is wrong or the shoe is too big. Use a heel lock lacing through the upper eyelets. Toe bang on descents means you need to lock the midfoot down harder, or your shoes are too small for downhill days.
Change socks at lunch and hang the wet pair on the pack to dry. Ten minutes with your shoes and socks off at a break does more than any product.
Not at the next break. A hot spot is a two minute tape job. A blister is three days of misery. This is the single highest return habit in hiking.
Keep a small blister intact. If it is large and will burst anyway, drain at the edge with a sterile point, leave the roof on as a dressing, and cover with a donut of moleskin so the rim takes the pressure.
Know your hot spots, tape before you walk, manage moisture, and stop the moment something feels warm.